J Am Coll Nutr 1998;17:235-8. A person whose vitamin B-12 levels are outside of the normal range will require treatment. Sometimes high blood levels can be attributed to serious diseases. The test can be carried out comfortably and quickly at home; though must be ordered online and can be expensive. On top of that, we know that only a small percentage of vitamin B12 taken orally is actually absorbed. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. The most common cause of high B12 in the blood is due to recent ingestion or injection of supplemental vitamin B12. Vitamin B12 helps in the formation of Red Blood cells. Certain people are more at risk of vitamin B-12 deficiency than others, especially those who have low stomach acid or other digestive issues. 5.7K views View 1 Upvoter Learn…, Having low blood pressure with a high pulse can be a normal response to certain situations, such as after exercising or standing up too quickly. Intrinsic factor is a substance in the stomach that binds to vitamin B-12 so that the body can absorb it. In this instance, transcobalamin is fully available but has problems bonding with vitamin B12 – there will thus also be a B12 deficiency, despite very high blood levels. Another method that requires a visit to the doctor for a blood test is the holo TC test, which only measures vitamin B12 that is bound to the transport molecules, transcobalamin. A high level of folic acid or folate in the blood indicates a person eats a diet that is high in folic acid, takes vitamins, takes folic acid pills or has a vitamin B12 deficiency, states WebMD. The following are Important functions performed by Vitamin B12; Red Blood Cell Formation. Sie können sich in Ihrem Konto anmelden oder sich registrieren. So if vitamin B12 levels are very low, folate can't be used by the cells, and high levels of it may build up in the blood. Probiotics for weight loss: What is the evidence? Alcoholic cirrhosis and cobalamin metabolism. Can a heart failure drug help treat long COVID symptoms? MNT is the registered trade mark of Healthline Media. Alternative Names. It measures the total amount of B12 in the blood, not distinguishing between active and inactive forms of B12. 0. Whilst low blood levels of vitamin B12 indicate deficiency in a test; elevated blood levels are also often discovered. Supplements are available in capsule or liquid form from pharmacies, supermarkets, health stores, and online. by: Kerri Knox, RN, The Immune Queen You cannot get an accurate blood test while on Vitamin B12 supplements. Implications cliniques de la découverte d’une hypervitaminémie B12 en médecine interne. Increased vitamin B12 levels are uncommon, because excess vitamin B12 is usually eliminated with urine. Deficiency of Vitamin B12 may cause megaloblastic anemia. An abnormal result from the basic test kit, is not enough to start treatment with us. Pernicious anemia is a form of megaloblastic anemia caused by poor vitamin B12 absorption. What to know about low blood pressure with a high pulse, Debra Sullivan, Ph.D., MSN, R.N., CNE, COI. Fremont S, Chamigneulle B, Gerard P, Felden P, Lambert D, Gueant JL, et al . This test is most often done when other blood tests suggest a condition called megaloblastic anemia. How to tell the difference between hemorrhoids and cancer, numbness and tingling in the hands and feet, people with conditions that reduce vitamin B-12 absorption, including, people who have had gastric bypass surgery, people who are taking medicines such as chloramphenicol, proton pump inhibitors, or H2 blockers. These lab values help detect a vitamin B-12 deficiency during the early stages. Signs and symptoms of deficiency include: Infants with vitamin B-12 deficiency may fail to thrive. Kalyoncu U, Buyukasik Y, Akdogan A, Karadag O, Bilgen SA, Kiraz S, et al. High serum folate levels can mask the symptoms of vitamin B-12 deficiency and make its neurological symptoms worse. Is soda bad for your health, and what are the options? Scand J Haematol 1978;21:243-9. High B12 levels in the blood are not necessarily a reason to panic, as they can stem from a number of different causes. Chiche L, Jean R, Romain F, Roux F, Thomas G, Canavese S, et al. Hereditary illnesses and the long-term use of B12 injections can sometimes trigger the production of antibodies that work against transcobalamin II, leading to the vitamin not being utilised properly (9). Trifecta offer a meal delivery service that focuses on healthful meals. Learn more about how it can affect the body and alternative options here. Learn more about the service, including how it works, the available menu plans, Low blood pressure is not usually an emergency. Dementia. How to Prepare for the Test. The vitamin B-12 level test checks how much vitamin B-12 is in the body. A doctor may recommend this test to people who have symptoms of a deficiency or who have a higher risk of low vitamin B-12 in the body. Should high blood levels occur during a course of vitamin B12, then another measurement should be taken 10 days after supplementation has ended. J Clin Biochem 1984;17:99-107. He may want to order a blood test, which is the only way to definitively find out if your vitamin B12 levels are high, as well as decide if further tests are needed to find the underlying cause. tumour Biol 1991;12:353-9. Parenteral vitamin B12 therapy of hyperhomocysteinemia in end-stage renal disease. Elevated blood levels of vitamin B12 are generally associated with increased amounts of proteins that carry vitamin B12 in the bloodstream or release of stored vitamin B12. This is especially true for vegans and long-term vegetarians. Am J Med 1989;88:141-4, Grindulis KA, Calverley M, Cox C . Vitamin B-12 results For urine tests, a normal range for MMA is under 3.8 mcg/mC. Stomach acid separates vitamin B-12 from food so that the body can absorb it more efficiently. Advances in Thomas Addison’s Diseases. Learn…. It often affects older adults or those who are lacking intrinsic factor. 2. The vitamin B12 level is a blood test that measures how much vitamin B12 is in your blood. Vitamin supplements can make up for a shortfall in the diet, especially for vegans and strict vegetarians. Individuals with low vitamin B-12 levels often require regular injections of the vitamin. This can be tested using a holo TC or MMA urine test, which only measure the usable B12 (holo TC) or the metabolic product (MMA test). Figures above 900 pg/ml are considered high, but certain cases have recorded four or even five figure values. 200 and 900 nanograms per milliliter (ng/mL), How Google search data can predict COVID-19 outbreaks, Neanderthal genes may influence COVID-19 severity, Alma Levant Hayden: First Black woman in the FDA. Research on the use of vitamin B-12 for specific activities and conditions shows: 1. The following groups of people are more likely than others to experience low vitamin B-12 levels: Doctors usually use a blood test to check vitamin B-12 status, but home urine tests are also available. Blood transcobalamin levels in malignant hepatoma. Scand J Haematol 1977;19:453-62. We include products we think are useful for our readers. Vitamin B12 levels are measured through a vitamin B12 level blood test, also referred to as a cobalamin test, according to MedlinePlus. After extensive blood testing my neurologist has not found a cause for my neuropathy. If a significant amount of your B12 is inactive, a test may show that you have normal B12 levels. The following mechanisms are responsible for high vitamin B12 blood values in such diseases: Below is a list of the most common diseases associated with very high vitamin B12 blood levels. Vitamin B-12, in combination with vitamin B-6 and folate (vitamin B-9), has been shown to control high levels of homocysteine in the blood. There is no risk of cancer from high B12 levels from SUPPLEMENTS. Levels above the vitamin B12 normal range are unlikely to occur from your diet, but overuse of supplements and certain medical conditions could cause an excess. Cobalamin metabolism in chronic myelogenous leukemia. While free, unbound B12 can produce high levels in a serum test; it has no biological function whatsoever.